Post-Doctoral Research Associate
in Cardiovascular Regenerative Medicine and Bioinformatics
WT – MRC Cambridge Stem Cell Institute
Applications are invited to join Dr Sanjay Sinha’s team at the Cambridge Stem Cell Institute (http://www.stemcells.cam.ac.uk/research/pis/sinha). We have pioneered the generation of vascular smooth muscle cells from human embryonic and induced pluripotent stem cells (iPSCs) via different embryonic lineages (Cheung et al., Nature Biotechnology 2012;30:165-73, Iyer et al., Development 2015;142:1528-41). Recently we used this approach to establish an in vitro model of vascular disease in Marfan syndrome using patient-derived iPSCs (Granata et al., Nature Genetics 2017;49:97-109).
The focus of this exciting disease oriented project will be to identify how embryonic lineage contributes to aortic disease and to develop further iPSC based models of aortic aneurysms (Ehlers-Danlos syndrome and ACTA2). The successful applicant will also work with Dr Paul Bertone for in depth bioinformatics analyses of these in vitro models (RNA-seq & ChIP-seq).
The advertised position is funded through a British Heart Foundation Program Grant for 5 years, thus allowing a highly motivated scientist to make a substantial contribution to the development of new treatments for aortic diseases and establish a career in cardiovascular regenerative medicine.
You will have a PhD with an extensive background in cell and molecular biology, experience with bioinformatics and a strong publication record. It is essential that you have excellent communication, writing and organisational skills and the ability to work collaboratively. Experience with human ES/iPS cells will be advantageous. Informal enquiries to Dr Sanjay Sinha (firstname.lastname@example.org) are encouraged. Applications at http://www.jobs.cam.ac.uk/job/14894/
Fixed term: The position is available from 1st Nov 2017 until 31st Oct 2022.
Only short-listed candidates will be contacted. Closing date: 2nd October 2017.